About Macular Degeneration
Living and Thriving
Resources
Our Grants
Caregiver’s Corner
News
About Us
Contact
Store
Get Involved
Go Back
Wet Macular Degeneration
Treatments for Wet Macular Degeneration
Go Back
Living and Thriving
Low Vision Resources
Emotional Well Being
AMD Diet and Nutrition
Legal and Benefits
Go Back
Low Vision Resources
Low Vision Rehabilitation
Assistive Technology for Age-related Macular Degeneration
Go Back
Resources
Videos about Macular Degeneration
AMDF’s Print Newsletter
Go Back
Videos about Macular Degeneration
Life with Macular Degeneration – Patient Stories
Low Vision Aids and Modifications
Disease and Treatment Education
Cooking Show
Go Back
Our Grants
Our Grants Program
Research into Age-related Macular Degeneration

Causes of Macular Degeneration

© 2025 American Macular Degeneration Foundation

The specific cause of macular degeneration is not conclusively known, but the interplay between known hereditary and environmental factors is complex. The more that scientists understand the mechanisms that cause the cells of the macula to deteriorate, the more potential treatments they can develop to slow or stop the disease. The challenges are great, because multiple genes are associated with AMD and environmental factors — such as smoking, diet and sun exposure — also impact the disease.

Learn more about the risk factors for macular degeneration.